Studying how fish diets may influence the development of intestinal disorders that may lead to cancer is very difficult. A new, advanced method is being applied by SEAFOODplus researchers in the project FISHGASTRO showing how DNA damage may be influenced. The method is extremely difficult to set up and run, so the fact that it has been possible to apply it is in itself remarkable. The very first results have been obtained. Two volunteers have completed the study and had their cells subjected to the COMET analysis. It is far too early to make wide conclusions, but the successful application of the new method is encouraging.
Authors: Nina Habermann, Gerda Pot, Anouk Geelen, Ellen Kampman, Beatrice Pool-Zobel and Elizabeth K. Lund
The aim of this study is to see whether various aspects of gut health improve if we ask people to eat two extra portions of fish a week for 6 months. The importance of this intervention study has recently been highlighted following the publication of a paper from The European Investigation into Cancer and Nutrition team showing the marked reduction in risk of getting colon cancer if you eat on average more than 40g of fish a day, which are about 2 portions a week. They cannot yet say whether it matters if the fish is oil rich or not so we are dividing our volunteers into people eating white fish and those eating oil rich fish as well as a control group eating no extra fish. All our
volunteers are patients going for colonoscopy anyway and they donate us for the study 4-8 biopsies, which are tissues samples from their large bowel weighing between 4-15 mg. They then get randomised to the different intervention groups and after 6 months they return specially for us, to give a few more biopsy samples. We also take detailed diet histories, blood samples and faecal samples during the study. We have now recruited in Holland and the UK over 40 people and three have completed the study. We aim to have 270 people complete by the end of the SEAFOODplus project so we are now expanding into more hospitals and involving more doctors.