Project leader is Dr. Albert Bosch of the University of Barcelona (UB). He is head of the Enteric Virus Group of the Department of Microbiology, which has been involved since 1979 in research on environmental virology, and particularly on the development of procedures for the detection and characterisation of human enteric viruses, notably astrovirus, rotavirus and hepatitis A virus. The stability of enteric viruses under natural and disinfection conditions is also a major research subject for the group. Research on hepatitis A virus started in 1986, covering many aspects of clinical, environmental and basic biology of the virus. Current tasks of the group include studies of viral safety assessment, which comprise standardised determination of HAV in blood derivatives. On the other hand, the group has been actively involved in the production of synthetic and recombinant hepatitis A virus immunogens.The Enteric Virus Group of the UB was the first university laboratory in Spain to receive the certification of Good Laboratory Practices compliance for validation studies of viral safety.